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Charles Mackay's work experience includes roles at Tenaya Therapeutics and The University of Tennessee Health Science Center.

At Tenaya Therapeutics, Charles currently holds the position of Research Scientist II - In-vivo Pharmacology and Toxicology. In this role, they lead and manages in-vivo biology studies, specifically evaluating the efficacy of small molecular target regulators in chronic heart failure and conducting target discovery and validation for cardiometabolic diseases such as obesity, heart failure with preserved ejection fraction (HFpEF), heart failure with reduced ejection fraction (HFrEF), and fatty liver disease.

Prior to their current position, Charles worked at The University of Tennessee Health Science Center. Charles served as an Assistant Professor in Physiology, where their research focused on investigating signaling mechanisms, trafficking, physiological functions, and blood pressure regulation of endothelial polycystin proteins (PKD1 and PKD2), TRP channels, Ca2+-activated Cl- channels, and Ca2+-activated K+ channels. Charles also presented faculty seminars and supervised and trained Ph.D. students during this time.

Before becoming an Assistant Professor, Charles worked as a Postdoctoral Researcher at The University of Tennessee Health Science Center. In this role, they investigated signaling mechanisms and physiological functions of polycystin proteins (PKD1 and PKD2) in endothelial cells. Charles provided coaching and supervision to new postdoc recruits, visiting scholars, and graduate students.

Overall, Charles Mackay has substantial research experience in the field of physiology and has contributed to advancements in understanding signaling mechanisms and physiological functions related to cardiovascular diseases and other cardiometabolic disorders.

Charles Mackay has an extensive education history in the field of biomedical science and physiology. Charles obtained their Bachelor of Science (BSc) (Hons) degree in Applied Biomedical Science from the University of the West of Scotland between 2007 and 2011. Following this, they pursued a Master's Degree in Molecular Medicine at the University of Glasgow from 2011 to 2012. Charles continued their academic journey at King's College London, where they completed their Doctor of Philosophy (Ph.D.) in Respiratory Physiology from 2013 to 2016.