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Alex Simon has had a varied career trajectory, beginning with their role as a Global Shaper for the World Economic Forum in 2011. Alex then joined Compass Partners as an Executive Director and Director of Strategic Partnerships from 2011-2016. In 2016, they began working at Oscar Insurance as a Network Expansion Project, and simultaneously at YNG Ventures as a Co-Founder, where they helped to launch YPO Next Gen, an organization for the children of Young Presidents Organization (YPO) members. Alex also joined NextGen Venture Partners as a Venture Partner in 2016. In 2017, they became a Partner at Wonderland Investments, and in 2018 they joined Alto Essentials as a Partner. In 2020, they began working as an Advisor for the Center for the Neuroscience of Psychedelics at the Massachusetts General Hospital, and in 2021 they became Co-Founder and Chief Of Staff at Sensorium Therapeutics.

Alex Simon completed their education history with a Master's program in Chairs from the Open Master's Program between 2012-2014. Prior to that, they obtained a Bachelor's Degree in International Relations and Affairs from The George Washington University between 2008-2012. Alex began their education journey in 2004 at Newton North High School, where they obtained their High School Degree.