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Brittany McDonough has a diverse work experience, beginning in 2016 as an Organic Chemistry Peer Tutor at UMass Lowell Centers for Learning. In 2017, they worked as an R&D Biosurgery Co-op at Getinge. The following year, they were an R&D Contractor at Getinge and a New Product Development Intern at Domaine Chandon. In 2019, they were a Project Manager, Project Engineer, Product Development Engineer, and Materials Engineering Intern at RevBio, Inc.

Brittany McDonough obtained a Bachelor of Science in Chemical Engineering from the University of Massachusetts Lowell between 2014 and 2019. Brittany then went on to pursue a Master of Science in Biomedical Engineering and Biotechnology at the same university, which they completed in 2020.