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Nicolas Plèche has a diverse work experience spanning different roles and industries. Nicolas started their career in 2005 as a Technicien de laboratoire at Démarche Expérimentale en Biologie. Nicolas then worked as a Manœuvre at SAS from 2003 to 2007. In 2007, they were a Stagiaire Master2 at Centre de Recherches du Service de Santé des Armées in the C.R.S. department. Nicolas later became a Technicien en Histologie at Scp Dusserre-Feutry-Kermanac'h-Istier-Cruel, Cabinet médical d'Anatomie-Pathologie from February to August 2010. From 2012 to 2012, Nicolas worked as a Research assistant at Institut de Biologie et de Chimie des Protéines-CNRS FRE3310. In 2013, they joined INSERM U855 Nutrition et Cerveau as a Research Assistant for the duration of 9 months. Currently, Nicolas Plèche holds two roles at Light Chain Bioscience | Novimmune SA. Nicolas started as a Bioprocess R&D Senior Assistant in May 2014 and is now serving as a Research Associate.

Nicolas Plèche pursued their education in the field of Biology. Nicolas completed their Bachelor's degree in Biologie, général at Lycée Berthollet, although the specific start and end years are not provided. Following this, they attended Université Joseph Fourier from 2002 to 2007, where they obtained a Master 2 degree and Maîtrise de l’anglais scientifique in the field of Biologie Cellulaire et Intégrative; Sciences du Vivant.