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Simon Mahler has a diverse work experience in the medical field. Simon started their career at the University of Michigan as a Research Technician from June 1996 to June 1998. Simon then worked as a Physician at Lexington Medical Center from July 2004 to June 2005, and at Morehead Memorial Hospital from September 2004 to June 2005.

In 2005, they joined the Louisiana State University Health Sciences Center where they served as an Instructor/Assistant Professor and Associate Residency Director in the Department of Emergency Medicine from July 2005 to June 2010.

Simon Mahler later joined Wake Forest School of Medicine where they held various positions. Simon started as an Assistant Professor in July 2010 and became an Associate Professor, Director of Clinical Research in the Department of Emergency Medicine from July 2014 to June 2019. Simon then served as a Professor and Director of Clinical Research from July 2019 to November 2021. Currently, they hold the position of Professor and Vice Chair of the Research Department of Emergency Medicine, starting from December 2021.

During their career, Simon Mahler also had roles outside of academia. Simon worked as the Chief Medical Officer at Decision Point Informatics from March 2016 to April 2017. Simon also served as the Chief Medical Officer at IMPATHIQ, starting from May 2017.

Additionally, Simon Mahler worked as a Physician at Wake Forest Davie Medical Center from October 2013 to June 2019.

Overall, Simon Mahler's work experience showcases their expertise and leadership in the medical field, particularly in emergency medicine and clinical research.

Simon Mahler's education history began in 1992 when they attended Kenyon College and earned a Bachelor of Arts (B.A.) degree in Biology in 1996. Simon then attended Michigan State University College of Human Medicine from 1998 to 2002 and obtained a Doctor of Medicine (MD) degree in Medicine. In 2002, Simon joined the Emergency Medicine Residency Program at Wake Forest University School of Medicine, where they completed their training until 2005.

From 2010 to 2012, Simon pursued further education at Wake Forest University Graduate School. During this time, they simultaneously enrolled in Wake Forest University and served as a Fellow of Quality Care and Outcomes Research in Cardiovascular Disease. Additionally, they earned a Master of Science (MS) degree in Clinical and Population Translational Sciences.

Simon Mahler also possesses the certification of FACEP from the American College of Emergency Physicians, though specific dates of obtaining this certification are not provided.