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Harlan Krumholz has been working at Yale University since July 1992, where they serve as the Harold H. Hines Jr. Professor. In addition, they co-founded Refactor Health in January 2019 and Hugo Health in February 2015.

Harlan Krumholz completed their Bachelor of Science degree in Biology from Yale University, where they studied from 1976 to 1980. Following this, they pursued their medical education at Harvard Medical School and received their MD degree between 1981 and 1985. Later on, they attended Harvard T.H. Chan School of Public Health, specializing in Health Policy and Management, and obtained their SM degree from 1990 to 1992.