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Niccolò Ramponi has a diverse work experience spanning several roles and industries. In 2017, they worked as a Fisioterapista at FisioFit and I.P.A.B. Chiampo, providing physical therapy services. Niccolò then joined ULSS 9 Verona - Medicina Fisica e Riabilitazione as a Fisioterapista from 2019 to 2020. In 2020, they also worked at ULSS 9 Verona as a Fisioterapista. In the same year, they founded and curated TEDxBolca, a local group focused on innovation within the international organization TED. Since 2018, Niccolò has served as the CEO and Co-Founder of FisioScience, a scientific publishing house that organizes accredited courses in Italy. Their current position is as a Junior Lecturer at Sapienza Università di Roma, starting in 2022.

Niccolò Ramponi has an extensive education history with a focus on healthcare and entrepreneurship. Starting in 2020, they pursued an Entrepreneurship Specialization through Wharton Online. Prior to that, from 2017 to 2018, they completed a Master's Degree in Musculoskeletal Disorders Rehabilitation (OMPT) at Università degli Studi di Genova. Earlier, from 2013 to 2016, they obtained a Bachelor of Science degree in Physiotherapy from Università degli Studi di Verona. Their secondary education took place at Liceo Scientifico "Leonardo Da Vinci" in Arzignano (VI), where they received a Diploma di Maturità, Scientifico/Tecnologico in 2013.

Along with their formal education, Niccolò Ramponi has also acquired several certifications. These include the Certificato di Test FisioScience CLUB and the Certificato di prova FisioScience CLUB from FisioScience, which they obtained in January 2023. Niccolò also completed the Startup School program offered by Y Combinator in March 2020. Additionally, they hold certifications such as the FIFA Medicine Diploma from The Fédération Internationale de Football Association (FIFA) in March 2019, the Physiotherapist (PT) certification from The Health and Care Professions Council in January 2019, and the Certified Strength and Conditioning Specialists (CSCS) certification from the National Strength and Conditioning Association (NSCA) in December 2018. Niccolò has also attained the Orthopaedic Manipulative Physical Therapist (OMPT) certification from the International Federation of Orthopaedic Manipulative Physical Therapists in October 2018. Furthermore, they have completed various specialized training programs, including Trigger Point Dry Needling - Level I from the Integrative Dry Needling Institute in June 2017 and the Personal Trainer FIPE certification from the International Weightlifting Federation in April 2016. Lastly, they are a member of the Mensa I.Q. Society, having been accepted in October 2016.