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Greg Spencer began their work experience in 1992 as the Chairman of Internal Medicine at Wilford Hall USAF Medical Center, a position they held until 1996. In 1996, they became a Partner at Crystal Run Healthcare. Greg later took on the roles of Chief Medical Information Officer and Chief Medical Officer at Crystal Run Healthcare. In 2008, they became the Chairman of Quality and Clinical Committee at NY e-Health Collaborative. Most recently, in 2017, they became an Assistant Professor at Albert Einstein College of Medicine.

Greg Spencer completed their Bachelor of Science in Bioscience at the University of Wisconsin-Parkside from 1981 to 1984. Following this, they pursued their medical education at the Medical College of Wisconsin, where they obtained their MD degree in Medicine from 1984 to 1988.