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Zhiyong Chen has extensive work experience in the field of biosciences and pharmaceuticals. zhiyong started their career at Trius Therapeutics Inc, a Cubist company, in 2007 as a research scientist. zhiyong worked in that role until 2014. In 2014, they joined Crinetics Pharmaceuticals as a senior research scientist but left the company in the same year. Later in 2014, they joined Cidara Therapeutics as a Principal Scientist and continued in that position until at least 2019. Since 2019, Zhiyong Chen has been working as a Principal Scientist at Kumquat Biosciences Inc.

Zhiyong Chen started their education journey in 1999 by pursuing a Doctor of Philosophy (Ph.D.) degree in total synthesis of Natural Products at The University of Hong Kong. zhiyong successfully completed their doctoral studies in 2002. Following this, from 2004 to 2007, Zhiyong Chen attended Scripps Research, specializing in Biochemistry and Molecular Biology. No specific degree name is mentioned for this period.