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Raphael Beaufret has held various roles in the field of healthcare and technology. From 2014 to 2019, they worked at Greater Paris University Hospitals, where they served as the Head of Transformation and later as the Head of Web Innovation Data department in the CIO Office. In 2020, they joined the Ministère de la Santé as the Projects Director for the Ministerial eHealth delegation (DNS), and subsequently became the Co-head of the Digital Health Ministerial Delegation. In 2023, they became the Chief Information Officer at Greater Paris University Hospitals.

Raphael Beaufret's education history includes a B.Sc and M.Sc in Biology, Chemistry, Computer Science, and Mathematics from École Polytechnique which took place from 2008 to 2012. Raphael also pursued a Master of Business Administration (MBA) at Collège des Ingénieurs from 2012 to 2013. In 2019, Raphael started studying at 42, but the end year is not specified. In 2011 and 2012, they attended AgroParisTech, earning an M.Sc in Microbiology and Virology. Additionally, in 2014, they obtained a certification in "Conduire un projet de sciences de données" from École Polytechnique, focusing on Data Science Starter Program (DSSP).