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Charlotte Safos has had a long and varied career in the technology industry. Charlotte started their career in 1995 as Special Projects Manager for United Cerebral Palsy. In 2003, they joined AnthroTronix as Chief Operating Officer and then became President and Chief Operating Officer. In this role, they were responsible for setting and overseeing policies and procedures for maximum efficiency, as well as budgeting, cost management, and leadership of financial and technical personnel. Charlotte also led the user-centered design process and directed the deployment of prototype technology in a clinical setting for testing and evaluation with end-users. This work resulted in the commercialization of an educational product line and creation of company subsidiary, AT KidSystems. In 2009, Charlotte became Vice President and General Manager of AT KidSystems, leading the entire life cycle product development process of software and hardware products.

Charlotte Safos completed their Bachelor of Arts in American Government at The Catholic University of America in 1985. Prior to that, they attended Canterbury School.