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Mani Neelamegan has a diverse work experience in the field of physiotherapy. From 1999 to 2001, they worked as a Junior Physiotherapist at Vellore Hospitals, where they gained experience in treating clients with various musculoskeletal, neurological, and respiratory conditions. Mani then joined Northshore Healthcare Services in New Zealand from 2001 to 2003, where they handled more complex cases and worked closely with a multidisciplinary team.

In 2003, Mani worked as a Customer Services Representative at Inland Revenue NZ before returning to the physiotherapy field. From 2004 to 2006, they worked at Pontypridd and Rhondda NHS Trust in the UK in various roles, including Senior II Physiotherapist and Senior I Physiotherapist, where they treated patients with neurological, respiratory, and orthopedic conditions.

Mani then joined Powys Local Health Board in the UK in 2006, where they served as a Reablement Physiotherapist until 2015. In this role, they managed clinical caseloads, supervised junior staff and students, and participated in interdisciplinary meetings. Mani focused on maximizing patient independence, mobility, and functional ability while collaborating with various stroke and falls services.

Currently, Mani Neelamegan is the Director and Lead Therapist at Ann Physiocare, a role they have held since 2009. In this position, they lead a team of professionals providing specialized physical therapy for musculoskeletal and neurological conditions, emphasizing preventative tools to keep patients injury-free. The physiotherapists at Ann Physiocare deliver hands-on treatment and prioritize assessing and treating conditions with quality care and time.

Mani Neelamegan completed a Bachelor of Physiotherapy degree from Sri Ramachandra Medical College and Research Institute, starting in 1994 and ending in 1998. Prior to that, from 1988 to 1994, they attended Holy Cross Matriculation Higher Secondary School and earned a Higher Secondary Certificate. The field of study for the Higher Secondary Certificate is not specified.