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Simone Moraes Mantovani has been working in the scientific field since 2007. Simone began as a PhD student at Universidade Estadual de Campinas in 2007, and then became a visiting PhD student at Caltech in 2009. In 2011, they became a postdoctoral researcher at Universidade de São Paulo, where they worked on the directed evolution of xylanases for increased performance in the degradation of sugarcane xylan. From 2012 to 2015, they were a scientist at the Scripps Institution of Oceanography, where they identified and elucidated the biosynthetic pathway of the Streptomyces-produced alkaloid Chlorizidine A. From 2015 to 2018, they were a scientist at Synthetic Genomics, where they worked on the discovery and development of novel genome editing technology and applied it to multiple host organisms. Currently, they are a scientist at Amyris, where they work on the development of the Universal Molecule Pipeline funded by DARPA to build and improve strains to produce hundreds of molecules simultaneously at grams/kilograms quantities.

Simone Moraes Mantovani has a diverse educational background. Simone obtained their Bachelor's degree in Chemistry from Universidade Estadual Paulista Júlio de Mesquita Filho in 2004, followed by a Master's degree in Organic Chemistry with focus in Biocatalysis from Universidade Estadual de Campinas in 2007. Simone then completed a PhD in Organic Chemistry with focus in Biocatalysis from Universidade Estadual de Campinas in 2011. From 2009 to 2010, they were a Visitor Student at Caltech studying Chemical Engineering. Simone was also a Postdoctoral Researcher at USP - Universidade de São Paulo in 2011 and a Postdoctoral Researcher at Scripps Institution of Oceanography (UCSD) from 2012 to 2015. Simone also completed a Post Doc at Scripps Institution of Oceanography focusing on Biosynthesis of natural products from marine bacteria.