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Peter MacDonald II has a diverse work history starting as a Programmer with the New England Patriots in 1993. Peter then moved on to roles as a Technical Manager/Sr Consultant at Creative Computing, Sr. BI Consultant at Ciber, Data Warehouse Consultant at The Revere Group, and eventually joined Biogen Idec in 2006. At Biogen Idec, they held roles such as Data Warehouse Consultant and Sr IT Architect, where they led various data management and analytics projects. In 2023, Peter MacDonald II transitioned to Wave Life Sciences as the Associate Director, Lead Discovery Data Architect and Engineering.

Peter MacDonald II completed their high school education at Randolph High School, earning a diploma in College/University Preparatory in 1988. Peter then went on to pursue a Bachelor of Science (B.S.) degree in Computer Science at Wentworth Institute of Technology, where they graduated in 1994. Additionally, Peter has obtained various certifications, including Docker Essential Training, Introduction to Machine Learning with KNIME, and MySQL Essential Training, among others.