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Simon Du has worked in the field of research since 2014. Simon began their career as a Program Counselor at the Discovery Museum and Planetarium in 2014. In 2016, they worked as a Research Associate at St. Vincent's Medical Center and as an Undergraduate Research Assistant and Administrative Assistant at the University of Connecticut. From 2019 to 2020, they worked at IsoPlexis as a Senior Research Associate and Research Associate. Currently, they are a Research Associate II at Walden Biosciences.

Simon Du obtained a Bachelor's Degree in Cell/Cellular and Molecular Biology from the University of Connecticut between 2014 and 2018.