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Manisha Cole has held various positions in the medical field since 2014. Manisha began their career as a Teaching Assistant and Special Assistant at New York University - Polytechnic School of Engineering from 2014 to 2017. Manisha then moved to Packard Health, where they held the roles of Medical Assistant and Medical Volunteer from 2017 to 2020. In 2020, Manisha joined Boston Medical Center (BMC) as a Research Assistant II and Microbiology Technologist. Most recently, in 2021, they began working at Boston University School of Medicine as a Senior Research Specialist. Manisha is currently employed as a Senior Associate, Life Sciences Program Management at Virgo since 2022.

Manisha Cole earned a Bachelor of Science in Biotechnology from New York University - Polytechnic School of Engineering between 2013 and 2018. Manisha then went on to obtain a Master of Science in Pathology and Laboratory Science from Boston University School of Medicine between 2019 and 2021. Additionally, they obtained a Basic Life Support for Healthcare Providers (BLS) certification from the American Heart Association in April 2019.