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Mark Fleming has extensive work experience in the field of oncology. Mark currently serves as the Genitourinary Disease Committee Chair at the Sarah Cannon Research Institute since 2023. Prior to that, they held multiple roles at Virginia Oncology Associates, including President and Founder/Chair of the Inclusion Council. Mark was also a Medical Oncologist at The US Oncology Network, where they served as Chair of the National Policy Board and the Genitourinary Committee. Additionally, they were the Associate Chair for GU Research at the same organization. In 2015, Fleming worked as the Division Chief of Hematology and Oncology at Eastern Virginia Medical School.

Mark Fleming received their Bachelor's degree in History and Sociology of Science from the University of Pennsylvania in 1988. There is no available information about their education before attending the University of Pennsylvania.