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Mark is an internationally recognized expert in the treatment of urothelial cancer and an active investigator and contributor to peer-reviewed literature in urologic oncology.

Mark has held prominent roles at several major universities, including the Bernard Schwartz Distinguished Professor of Urologic Oncology at Johns Hopkins University from 2005 to 2014.

Under the auspices of The American Cancer Society, Mark completed his fellowship in urologic oncology at The James Buchanan Brady Urological Institute of Johns Hopkins University. He served as a resident in surgery and urology at the Hospital of The University of Pennsylvania and received his doctor of medicine from The University of Texas (Houston) and his undergraduate degree from Yale University.

Mark is a founding member of the scientific advisory board of The Bladder Cancer Advocacy Network.