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Lou was born in Harriman with the help of her grandmother, who was the midwife. She graduated from Maryville High School and has deep family roots in Cades Cove. Lou started her career with Uplands Village in 1995 as a charge nurse. She completed her RN degree (with help from Uplands Scholarship) and became the Director of Nursing in 2004.

Lou left Uplands briefly in 2007 and became the Director of Nursing at Bordeaux Long Term Care facility in Nashville. She returned to Uplands Village in 2015 and later received her Nursing Home Administrator Licensure before retiring in 2019.

Lou has been a Wound Certified Nurse since 2008 and chose to return to Uplands as a wound nurse in 2021. She has also worked as a Tennessee CNA test proctor for 22 years and was on the Tennessee Advisory Board for CNA programming for ten years.