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Sander Nagtegaal has worked in various roles since 1999. Sander began their career at C-Factory as a Technical Manager, followed by a role as a Senior Business Analyst at Evident Interactive BV. In 2003, they became an Enterprise Architect and Technology Officer at Centrical, their current holding company. In 2005, they were appointed Chief Architect at Albumprinter (now Albelli), where they were responsible for innovation and directing a team of over 30 software developers. In 2009, they co-founded Peecho, a company which helps digital publishers distribute and fund their creative work. In 2013, they became the CTO of Altavia Sumis, a marketing resource provider. In 2015, they were appointed CTO of myTomorrows, a company which helps patients and their physicians get access to drugs in development. In 2017, they became the CEO and Co-Founder of Unless.com, a no-code feature component platform.

Sander Nagtegaal attended Scholengemeenschap Noordendijk from 1987 to 1993, where they obtained a VWO degree. Sander then went on to pursue a Master of Science in Geophysics from Utrecht University from 1993 to 1999.