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Clare Quarrell has a strong background in communications and marketing. Clare began their career as a Marketing and Communications Assistant at CMS Cameron McKenna LLP in 2003 and worked there until 2006. Clare then joined the National Children's Bureau (NCB) and held various roles including Senior Media Officer, Acting Head of Communications, and eventually became the Head of Communications in 2011. At NCB, Clare was responsible for developing and implementing integrated communication strategies, managing a team, and overseeing a budget of £500,000. During their time at NCB, they significantly increased the organization's media coverage and secured corporate sponsorships. In 2016, Clare joined UNICEF UK as the UK Strategic Communications Lead, where they continue to work.

Clare Quarrell attended Cardiff University / Prifysgol Caerdydd from 1999 to 2002, where they obtained a BA degree in Journalism, Film and Broadcasting.