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Liesbeth De Boom's work experience begins with an internship at Schering-Plough in 2007. Liesbeth then worked as a Junior Industrial Pharmacist at Baxter Healthcare in 2008. In 2009, they became a Responsible Pharmacist at Baxter Healthcare and later transitioned to the role of QA Manager/Qualified Person at PSI supply. By 2011, Liesbeth joined UCB Pharma as a Qualified Person in Pharma Manufacturing and was later promoted to CMO Manager. At UCB, they held the roles of Associate Director CMO Management and Device Development and Industrialisation Lead before becoming the Procurement Lead for Devices & Packaging in 2022.

Liesbeth De Boom completed their education in two institutions. From 1995 to 2001, they attended Sint-Maarteninstituut Aalst, where they pursued a degree in Wetenschappen-wiskunde. Later, they enrolled at Ghent University from 2001 to 2007 to study Pharmaceutical Sciences, specializing in Industrial Pharmacist/QP. In terms of additional certifications, Liesbeth obtained a certification in Negotiation Foundations from LinkedIn, although the specific month and year are not provided.