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Bénigne MATHIEU has a long and varied work experience. Bénigne began their professional career in 2006 as a freelancer, creating medical websites. In 2009, they joined AstraZeneca, where they held a variety of roles, including Directeur de Business Unit CardioVasculaire Rénal et Métabolisme, Directeur de Franchise Cardiovasculaire, Directeur de réseaux Cardiovasculaire, Chef de Gamme Cardiologie, Chef de produit Cardiovasculaire, Médecin Chef de Projet Neurosciences, and Médecin Chef de Projet Respiratoire. In 2022, they joined Tilak Healthcare as Chief Business Officer.

Bénigne Mathieu attended ESCP Business School from 2008 to 2009, where they earned a MSM in Marketing Pharmaceutique. From 1996 to 2006, they attended Faculté de Médecine de Dijon, where they earned a Docteur in Médecine Générale.