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Marie-Liesse Asselin-Labat's laboratory is studying mechanisms controlling lung health and how those mechanisms are altered in respiratory disorders.

Marie-Liesse is studying the cellular interactions and molecular pathways controlling lung health, from lung development through adulthood, and how these mechanisms go awry in lung diseases. The goal of the research is to understand how lung diseases occur to identify novel therapeutic targets.

The research focuses on studying the lung epithelium and the role of surrounding immune cells in maintaining lung health and controlling lung cancer formation. They work with preclinical models as well as clinical samples to assess the role of immune cells in maintaining lung homeostasis. They investigate mechanisms developed by tumor cells to escape immune surveillance. Their aim is to identify ways to reactivate immune activity against cancer cells with the ultimate goal to improve outcomes for people with lung cancer.