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Isabelle Lucet's work addresses the fundamental questions underlying how the malfunction of proteins can lead to the deregulation of key cellular processes and the establishment of diseases. Their focus is on studying the malfunction of protein kinases, a specific type of signaling proteins that act as transmitters in cells and govern nearly all biological processes.

Isabelle's research is unraveling new kinase-controlled signaling pathways and identifying the mechanisms that lead to ā€œout of controlā€ signaling, a common cause of cancers and inflammatory disorders. They use the basic research discoveries to develop novel therapeutic strategies to counteract kinase-driven diseases.