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John has extensive experience gained from building and managing the translation of RNAi from a Nobel Prize-winning discovery into an innovative, entirely new class of medicines, and in the process creating one of the biopharmaceutical industry’s largest and arguably most successful companies.

John has served as the CEO and a Director of Alnylam since 2002. Prior to Alnylam, John served as an officer and a member of the management team for Millennium Pharmaceuticals, and prior to that he held various positions at Biogen, where he invented and led the discovery and development of ANGIOMAX® (bivalirudin) for injection, formerly HIRULOG™ and currently marketed by The Medicines Company. Prior to Biogen, John was a scientist at ZymoGenetics, Inc., and the Upjohn Company. John also formerly served as Chair of the Board of Directors for the Biotechnology Industry Organization (BIO). John received his MS and PhD in biochemistry and molecular biology at the University of Chicago.