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Karen Guyer's work experience begins in 1996 as an Account Manager at Creative Action Design. Karen then worked as an Operations Manager at MetaDesign from 1999 to 2001. Following that, they held the position of Senior Account Director at Interbrand in 2002, and then became a Client Director at FITCH from 2003 to 2006. Karen later served as an Account Director at Wolff Olins in 2006 and as Client Services Director at The One Off from 2007 to 2009. In 2014, they worked as a Consultant before joining KISS Communications in 2015 as an Account Director. In 2018, they became a Client Partner at Omobono until 2022 when they transitioned to The Marketing Practice, initially as a Client Partner and currently holding the position of Global Brand Solution Director.

Karen Guyer attended the University of Hertfordshire from 1998 to 2002, where they earned a Master of Business Administration (MBA) with a focus on Business Administration and Management. Prior to that, they studied at Nottingham Trent University from 1992 to 1996, completing a Bachelor's degree in Interior Architecture.