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Dr. Irwin received her Bachelor of Science at the Massachusetts Institute of Technology and Medical Degree from Harvard Medical School. She completed residency and fellowship training in paediatrics and Haematology/Oncology at Boston Children’s Hospital and Dana-Farber Cancer Institute at Harvard Medical School in Boston, Massachusetts followed by a research fellowship in the laboratory of Dr. William Kaelin, a Howard Hughes Medical Investigator at the Dana-Farber Cancer Institute studying the role of the p53-related genes, p73 and p63, in cancer.  After three years on faculty at Dana-Farber Cancer Institute, Dr. Irwin joined the Division of Haematology/Oncology at The Hospital for Sick Children (SickKids) in April 2002 as a Clinician-Scientist.