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Diane Redfern-Tofts has a range of work experience in research and management roles. Diane began their career as a Senior Bookseller at Waterstones from October 2006 to August 2010. Diane then worked as a Research Assistant at the University of Bradford from May 2010 to July 2013. Diane then transitioned to the MS Society, where they worked as a Care and Services Research Officer from July 2013 to February 2016, and as an Evidence Manager from March 2016 to April 2017. Currently, Diane is employed at The Health Foundation as an Assistant Research Manager since May 2017, and was later promoted to Research Manager in January 2019.

Diane Redfern-Tofts earned their Bachelor of Arts (B.A.) degree in Interdisciplinary Human Studies from the University of Bradford, completing their studies in 2006. Diane later pursued a Master's degree in Psychology at the same university, which they obtained between 2008 and 2009.