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Joseph Toth has worked in a variety of roles in the scientific field since 1991. Joseph began their career as a Graduate Student at Yale University, followed by a Postdoctoral Associate role at the Boston Biomedical Research Institute in 1999. In 2005, they moved to Merrimack Pharmaceuticals as a Senior Scientist, then to Adnexus, a Bristol-Myers Squibb R&D Company in 2008, where they held the same role. In 2013, they transitioned to Bristol-Myers Squibb as a Senior Research Investigator II. Most recently, they have been working at Tectonic Therapeutic, Inc. since 2019, where they have held both the role of Director and Principal Scientist.

Joseph Toth completed their PhD in Molecular Biophysics and Biochemistry from Yale University in 1998, after studying there from 1991.