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John Simms has a diverse work experience, starting in 1990 as a Project Engineer at C&S Consulting Engineering. John then worked at Bristol Myers Squibb in Syracuse, NY, from 1995 to 2008, where they held the role of Group Leader - Technical Services / Facilities. Currently, they are the Facilities Director at Syracuse Research Corporation, a position they have held since 2008.

From 1986 to 1989, John Simms attended the University at Buffalo, but did not earn a degree or specialize in any particular field of study.