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Dru Ledbetter has a diverse work experience in various roles and industries. Dru started their career as a Staff Nurse at Brigham and Women's Hospital in 2005 and later worked as a Staff Nurse/Charge Nurse at Quincy Medical Center. In 2009, they became a Nurse Manager at Radius Specialty Hospital, where they managed nursing operations for two years. Following that, they joined Northside Hospital as a Clinical Supervisor and later served as a Nurse Manager at Wellstar Health System, overseeing a 24-bed Acute Care Renal unit and Inpatient Acute Dialysis unit. In 2015, Dru joined Philips Capsule as a Clinical Project Manager, where they played a role in clinical implementations and served as a clinical product subject matter expert. Dru then transitioned to become the Owner and President of MAC Vernet Consulting in 2007, providing expertise in clinical workflow, project management, and product management. Currently, Dru is the Customer Success Director at SQUID iQ, Inc.

Dru Ledbetter completed a Bachelor of Science in Nursing (BSN) from Boston College from 2000 to 2004. Currently, Dru is pursuing a Master of Business Administration (MBA) in Healthcare Informatics from Southern New Hampshire University, scheduled to be completed in 2024. Before attending Boston College, Dru attended Boston Latin School, but the specific degree and field of study are not provided.