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Mackenzie Spellman has a diverse work experience in various roles and industries. In 2009, they started as a Teaching/Counseling Intern at The New School in the Heights. From 2010 to 2011, they worked as a Teaching Assistant at the University of Houston. Simultaneously, they also started working as a Data Collector and later became a Research Assistant II/Coordinator (Non-Clinical) at The University of Texas Health Science Center at Houston in 2009. In 2013, they served as a Clinical Psychology Graduate Student Intern at Houston Eating Disorders Center, LLC, and as a Research Assistant at Houston OCD Program. Mackenzie then joined The University of Texas Health Science Center at Houston in 2014 in multiple roles, including Psychologist Associate, Research Associate, and Research Coordinator I. Currently, they hold the position of Clinical Project Manager at Slope, starting in 2022.

Mackenzie Spellman completed their Bachelor of Science (BS) degree in Psychology at the University of Houston from 2007 to 2010. Later, they pursued a Master's Degree in Clinical Psychology at the University of Houston-Clear Lake, which they received from 2011 to 2013.