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Karie Spell started their work experience in 1998 as the Vice President and Administrator at Signature Health Services - Houston. Karie held this role until present. In 2015, they joined Signature Select Services as a Director, a position they held until 2017.

Karie Spell attended Texas Tech University Health Sciences Center where they pursued a Bachelor of Applied Science degree in Registered Nursing/Registered Nurse. Their education history started in 1994 and the end year is not provided.