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Holly Seher has a diverse work experience in various roles and industries. Holly began their career as a Graphic Designer at INTRAV in 1998 and worked there until 2002. From 2002 to 2006, they served as a Marketing Coordinator and Software Trainer at Pelarious, Inc. In 2006, Holly joined MilliporeSigma, where they held multiple positions including Electronic Publishing Coordinator, Sr. Publication and Promotion Specialist, Marketing Communications Supervisor, and Creative Services Manager. Their most recent role at MilliporeSigma was as a Creative Director, which they began in 2016. Throughout their career, Holly has gained expertise in areas such as branding and brand governance, conceptual design, digital publishing, web and print publishing, trade show and presentation design, sales collateral design and production, digital asset management, and operational excellence.

Holly Seher obtained a Bachelor's degree in Communication from Saint Louis University, graduating in 1998. In 2018, they obtained a certification in Preventing workplace harassment from Emtrain.