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Brian Hart has extensive work experience, starting in 2004 as an Analyst at Avascent. Brian then worked as a Research Assistant at Georgetown University Law Center in 2006-2007. From 2008 to 2015, Brian was a Senior Associate at Paul, Weiss, Rifkind, Wharton & Garrison LLP. In 2015, they became the CEO of KEYS for the Homeless until 2017. In 2017, Brian co-founded LightHouse DC, where they served as CEO. In 2019, they co-founded both RheumaGen and Vida Biomedical LLC, serving as the Chief Operating Officer in both companies.

Brian Hart completed their Bachelor of Arts (B.A.) degree in Economics and English from Amherst College from 1999 to 2003. Brian then pursued a Doctor of Law (J.D.) degree from Georgetown University Law Center from 2005 to 2008.