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Dr. Sharpless is the 2002 Nobel Laureate in Chemistry, known widely for his contributions to olefinic additions. His studies with many colleagues and fellows at the neighboring Scripps Research Institute (TSRI) and with Dr. Taylor began in 2001 and have led to the development of new landscapes for nicotinic acetylcholinereceptor ligands and cholinesterase inhibitors and reactivators. Noteworthy areas of innovation in the field of cholinesterase reactivation include: REG-001, our selected antidote from our robust library of hydroxyiminoacetamido alkylamines.