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Piotr Sliz has worked in various positions in the research and healthcare industries since 1999. Piotr began their career as a Bioinformatician/Post-doc at the Howard Hughes Medical Institute in 1999. From 2002 to 2016, they were an Associate Professor and Lecturer on Biological Chemistry and Molecular Pharmacology at Harvard Medical School, as well as the Director of the Summer Scholars Program and Assistant Professor. During this time, they also established the computing infrastructure to support Cryo-electron microscopy (cryo-EM) and developed SBGrid. In 2016, they became the Chief Research Information Officer at Boston Children's Hospital, where they led the Research Computing group and developed projects such as Pediatric Scholar research support program, Children's Rare-Disease Cohorts Genomics Initiative, data science program, and a Longwood-wide CryoEM computing initiative. Also in 2016, they co-founded Twentyeight-Seven Therapeutics, which is focused on the modulation of functional non-coding RNA (ncRNA) to treat cancer and other human diseases.

Piotr Sliz's education history includes a PhD from the University of Toronto in Structural Biology (Emil Pai Lab, Biochemistry) from 1995 to 2000, an HHMI Post-doc/Bioinformatician from Harvard University from 1999 to 2001, and a Bachelor's degree in Biochemistry from the University of Toronto from 1992 to 1995.