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David Keen has extensive work experience, starting in 1994 as an Editor for Sawasdee Magazine, an inflight magazine of THAI. David worked in editorial and creative roles until July 1996. In that same year, they co-founded QUO, where they served as Founder and CEO. David later became the Founder and CEO of the company again, with their tenure lasting until the present day. Most recently, in 2021, they co-founded KUBE Ventures as a Co-Founder.

David Keen attended Cornell University from 1984 to 1987. David studied Hotel Administration/Management during their time at the university. No specific degree was mentioned.