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Gregory M. Lee has a diverse work experience in the field of biophysics and protein-ligand interactions. Gregory M. started their career in 1999 as a Postdoctoral Fellow at the University of British Columbia, where they utilized NMR techniques to characterize the structural and dynamic properties of various proteins. Gregory M. also served as a research associate, training graduate students and postdocs in biomolecular NMR and protein molecular dynamics. Additionally, Lee worked as an NMR Consultant at Tekmira Pharmaceuticals, where they provided expertise in NMR technology.

In 2007, Lee joined UCSF as a Post-Doctoral Scholar and later became an Associate Specialist. During their time at UCSF, they focused on characterizing small-molecule and fragment inhibitor binding modes against several proteases and initiated a screening project for HIV Vif complex/APOBEC inhibitors. Gregory M. also managed the GE/ÄKTA FPLC Demonstration Lab and acted as a liaison between General Electric and UCSF.

In 2016, Lee joined UCSF/Small Molecule Discovery Center as a Specialist/Biophysicist. In this role, they characterized protein-ligand and protein-protein interactions using LC-MS and Surface Plasmon Resonance. Gregory M. worked on various projects, including Taspase-1 and p97, and supported multiple internal and external collaborations.

Most recently, in 2022, Lee joined Quanta Therapeutics as a Senior Scientist. The details of their work in this role are not yet provided.

Gregory M. Lee obtained a Bachelor of Science degree in Chemistry from the University of California, Davis, from 1987 to 1991. Gregory M. later pursued further education and earned a Ph.D. in Chemistry from the University of Washington, completing their studies between 1991 and 1999.