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Bruce Culleton began their career as an Associate Professor at the University of Calgary, where they played a key role in establishing the Alberta Kidney Disease Network (AKDN). The network focused on various research initiatives related to kidney disease. Bruce then joined Baxter International Inc., where they served as Vice President for nearly nine years. Following their time at Baxter, they worked at Becton Dickinson as a World Wide Vice President, handling medical affairs and global clinical development. Bruce then held multiple positions at CVS Health, starting as Vice President and Chief Medical Officer of Kidney Care and later becoming Vice President and General Manager of CVS Kidney Care. Currently, they hold the role of Chief Executive Officer at ProKidney Corp. and was previously the Executive Vice President of Clinical Development and Commercialization at the same company.

Bruce Culleton earned a degree in Medicine, specializing in Nephrology, from Memorial University of Newfoundland between the years 1987 and 1997. Bruce then pursued a study of Epidemiology, specifically focusing on the Framingham Heart Study, at Boston University from 1997 to 1999. In 2009, Bruce obtained an MBA from Northwestern University's Kellogg School of Management.