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Dr. Powis is the Director of the NCI Designated Research Cancer Center at the Sanford Burnham Medical Research Institute (SBMRI) in San Diego California. Former Chair of Experimental Therapeutics and Director of the Center for Targeted Therapy at The University of Texas M. D. Anderson Cancer Center, Dr. Powis is a leader in the field of signal transduction and has extensive experience in the development of anticancer drugs that act against cell signaling pathways including those involving PH domain regulated proteins. Dr. Powis has over 350 publications, and books, 12 patents and has been involved in the development of three anti-cancer agents that are now in clinical development.