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Guoning Mo has worked in a variety of roles since 1999. Guoning began as a Postdoctoral Researcher at North Carolina State University and Queen's University. In 2002, they moved to Toronto Research Chemicals where they served as a Senior Scientist. In 2013, they took the position of Chief Technology Officer at Hunan Ouya Pharmaceutical Co., Ltd. and held the same role at Suzhou Fushilai Pharmaceutical Co., Ltd. from 2015 to 2020. Currently, they are a Technical Director at Raybow Pharmaceutical.

Guoning Mo began their educational journey in 1981 when they attended Sun Yat-sen University, where they earned their Bachelor's degree in Chemistry in 1985. Guoning then continued their studies at Sun Yat-sen University, earning their Master of Science degree in Analytical Chemistry in 1989. Finally, they went on to pursue their Doctor of Philosophy degree in Organic Chemistry at the University of New England (AU), which they completed in 2001.