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Simon Bushell originally trained as a protein crystallographer and completed undergraduate studies at Monash University where he also completed his PhD in the lab of Professor Jamie Rossjohn. Simon then relocated to the United Kingdom to work as a Research Fellow at the University of St Andrews with Professor Jim Naismith at the Scottish Structural Proteomics Facility

In 2013, he joined the Structural Genomics Consortium, a research department within the University of Oxford, exploring the structural characterisation of human ion channels and other high-impact membrane protein targets.

Simon joined Orbit Discovery in 2019, establishing the Target Biology group to produce high quality target protein and to use structural biology to inform screening campaigns and experiment design.