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Ezgi Güler began their career in 2012 as a Swimming Coach at Ankara Hitit Gençlik ve Spor Kulübü. In 2015, they became an intern at Kardiosis Tıbbi ve Elektronik Ürünler San. ve Tic. A.Ş. Ezgi then worked as an Intern at Ankatech Bilişim Ltd. from 2016 to 2017. From 2017 to 2019, they worked as a Quality Assurance Engineer at Getinge Group. From 2019 to 2021, they worked as a QA & RA Manager at BMT Calsis Sağlık Teknolojileri San. Tic. A.Ş. and from 2021 to 2022, they worked as a Senior Quality & Regulatory Engineer at NuvoAir.

Ezgi Güler obtained a Bachelor's degree in Biyomedikal Mühendisliği from TOBB Ekonomi ve Teknoloji Üniversitesi between 2012 and 2017. Ezgi then went on to earn a Master's degree in Kalite Mühendisliği from Baskent University between 2017 and 2019. Güler also has a variety of certifications, including 2017/745/EU MDR Expert, Biyolojik Ürünler ve Biyobenzerler from Klinik Araştırmalar Derneği- Turkish Clinical Research Association, ISO 13485:2016 Baş Denetçi Eğitimi from Kiwa Türkiye, Klinik Araştırmalar Saha Görevlisi (Koordinatörlüğü) (Ver 2.0) from Klinik Araştırmalar Derneği- Turkish Clinical Research Association, Klinisyenler için İstatistik Anlama Temel Kursu from Klinik Araştırmalar Derneği- Turkish Clinical Research Association, Temel İyi Klinik Uygulamalar (Ver 2.0) from Klinik Araştırmalar Derneği- Turkish Clinical Research Association, Tıbbi Cihaz Ticarileştirme Eğitimi from Ankara Kalkınma Ajansı, ileri İyi Klinik Uygulamalar (Ver 2.0) from Klinik Araştırmalar Derneği- Turkish Clinical Research Association, 2017/745 Medical Device Regulation from Kiwa Türkiye, ISO 13485:2016 from CONSULTEAM Management Systems Consultancy Ltd., ISO 9001:2015 from CONSULTEAM Management Systems Consultancy Ltd., 2014/68/EU PED and EN 13445 from TÜV AUSTRIA TURK, ISO 14001:2015 from Şebnem Parlak, Üretim Yönetimi Eğitimi from İstanbul İşletme Enstitüsü, İş Hayatında Geri Bildirim Eğitimi from İstanbul İş