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Dr. Voot Yin is an internationally recognized expert in regenerative biology and medicine. His research focuses on defining the genetic circuits that underlie tissue and organ regeneration. Dr. Yin pioneered the use of comparative and evolutionary approaches to understand how some animals maintain robust regenerative capacity throughout their lives and why most mammals including humans have limited regenerative power that declines further during the aging process.

Dr. Yin pioneered the use of the zebrafish as a novel drug screening platform to identify small molecules capable of stimulating regeneration in humans. This powerful screening approach led to the discovery of MSI-1436. Dr. Yin has led the development of RegenDbase, a computational tool that provides a systems-level view of genes across models of tissue regeneration to advance knowledge of regenerative biology and stem cell self-renewal. RegenDbase facilitates new hypotheses about how genes regulate the regenerative response by integrating mRNA and microRNA expression data from diverse models of regeneration together with data from embryonic and induced pluripotent stem cells.

Dr. Yin holds a bachelor’s degree from Bates College, a Ph.D. in genetics from the University of Utah and completed postdoctoral training at Duke University. He received a prestigious Young Investigator Award from the American Heart Association in 2011. His research has been funded by the National Institutes of Health, the American Heart Association, the Department of Defense and private foundations. Dr. Yin is Novo Biosciences’ Chief Scientific Officer. In 2017, he was awarded a Direct to Phase 2 SBIR grant from the National Heart Lung and Blood Institute to test the efficacy of MSI-1436 in stimulating the regeneration of heart muscle following ischemia/reperfusion injury in the pig.