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Domenic DiSiena began their work experience in 2006 as a Manager of Business Planning and Customer Development at Schering Pharmaceuticals. Domenic then moved to Mars in 2008, where they held various roles, including Trade Investment Manager and Sales Lead. In 2012, they joined Unilever as a Customer Business Manager and later became the Channel and Customer Marketing Lead. In 2016, they joined L'Oréal as the Director of Ecommerce and Shopper Marketing. After that, they worked at Newell Brands as the Director of Global Ecommerce, focusing on Business Development and Trade Marketing. Currently, they are the Vice President of Ecommerce at Nestlé Health Science since 2019.

Domenic DiSiena holds a Bachelor of Science degree in Finance, Business Management, and Statistics from Seton Hall University. No specific dates for their education are provided.