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Po-Shun Lee has held a variety of roles in the medical field since 2010. Po-Shun began their career at Vertex Pharmaceuticals as Associate Medical Director of Clinical Development in 2010. In 2011, they became Founding Scientist and Advisor at BioAegis Therapeutics, Inc. and then in 2013, they moved to Novartis Institutes for BioMedical Research as a Translational Medicine Expert. In 2014, they became Chief Medical Officer and EVP, as well as VP Clinical Development at Proteostasis Therapeutics, Inc. In 2015, they joined Tufts Medical Center as part of the Pulmonary and Critical Care Division. In 2019, they assumed the role of Managing Partner at Puddingstone Spark LLC and Advisor to the Board at Nephroceuticals. In 2020, they became Chief Medical Officer at Platelet BioGenesis and Director of the Board of Directors at Metis Pharmaceuticals Inc. Most recently, in 2021, they became Chief Medical Officer at Generian.

Po-Shun Lee received a MD from the University of Pennsylvania School of Medicine and a BA in Biology from The Johns Hopkins University.