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Dr. Spear has been working in oncology and gene therapy research and development for over 30 years. He received a B.A. degree from the Johns Hopkins University and an M.D. degree from Stanford University. His post-graduate training was in the Massachusetts General Hospital/Harvard University.

He served as Vice President at Incyte and Sangamo Therapeutics, and Chief Medical Officer at Poseida Therapeutics.

His broad range of experience includes CAR-T cell, RMAT, Gene Therapy, Gene Editing, AAV, HSV, transposon, hemophilia, Oncology, Hematology, NHL, myeloma, AML, MDS, prostate cancer, lung cancer, breast cancer, pancreatic cancer, GBM, H&N cancer, sarcoma, and ovarian cancer.