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Sarah O'Callaghan has a diverse work experience. Sarah began their career as a Membership & Policy Executive at the South Dublin Chamber of Commerce from 1999 to 2004. O'Callaghan then worked as the Head of Public Affairs & Communications at The Alzheimer Society of Ireland, where they established and led a new division. Sarah joined IPPOSI - Irish Platform for Patients' Organisations, Science & Industry as a Board Member in 2012. O'Callaghan then moved on to AbbVie, where they held the roles of Patient Relations Manager from 2011 to 2015 and Government Affairs Manager from 2015 to 2016. Sarah is currently the Head of Marketing & Communications at LauraLynn, Ireland's Children's Hospice since 2016.

Sarah O'Callaghan has a diverse educational background. Sarah started their education at St Joseph of Cluny, Killiney from 1979 to 1985. The specific degree they obtained or field of study during this time is unknown. Later, from 1986 to 1989, they pursued a Bachelor of Arts degree in Honours Psychology at University College Dublin. Following that, in 1989 to 1990, Sarah attended LSB College and completed a Post Grad Diploma in Business Studies. Their most recent educational endeavor took place from 2008 to 2010 when they pursued a Masters degree at Dublin City University in Political & Public Communication.